河北省邯郸市盛鹏制造有限责任公司

SR-121463ACAS;185913-79-5
价格:12000元/公斤含量:99%包装:25公斤
CAS;185913-79-5
分子式：C17H22ClNO3
分子量：323.8228
化学名称 N-tert-Butyl-4-[5-ethoxy-4-[2-(4-morpholinyl)ethoxy]-2-oxospiro[cyclohexane-1,3-indolin]-1-ylsulfonyl]-3-methoxybenzamidefumarate
Thereductionofdiethyl3-(methoxymethoxy)glutarate(I)withLiAlH4inTHFgives3-(methoxymethoxy)pentane-1,5-diol(II),whichistreatedwithTs-OHandTEAinTHFtoyieldthedisulfonate(III).Thecondensationof(III)with5-ethoxyindolin-2-one(IV)bymeansoftBu-OKinTHFaffordsthespirocompound(V),whichisdeprotectedwithHClinmethanoltoaffordthespiranicalcohol(VI).Theoxidationof(VI)withpyridiniumchlorochromate(PCC)overAl2O3providesthespiraniccyclohexanone(VII),whichistreatedwith2-chloroethanol(VIII)andMs-OHintoluenetogivetheketal(IX).Thereactionof(IX)withzincborohydrideandtrimethylsilylchlorideinethylether/dichloromethaneyieldsthe2-chloroethoxyderivative(X),whichiscondensedwith4-(N-tert-butylcarbamoyl)-2-methoxybenzenesulfonylchloride(XI)bymeansoftBu-OKinTHFtoaffordtheadduct(XII).Finally,thetargetcompoundisobtainedbycondensationof(XII)withmorpholine(XIII)bymeansofNaIinDMF,followedbytreatmentwithfumaricacid.