贵州省黔东南州凯里市剑辉化工制造有限公司

SR-121463A185913-79-5
价格:10000元/公斤含量:99%包装:25公斤
CAS;185913-79-5
分子式：C17H22ClNO3
分子量：323.8228
化学名称 N-tert-Butyl-4-[5-ethoxy-4-[2-(4-morpholinyl)ethoxy]-2-oxospiro[cyclohexane-1,3-indolin]-1-ylsulfonyl]-3-methoxybenzamidefumarate
Thereductionofdiethyl3-(methoxymethoxy)glutarate(I)withLiAlH4inTHFgives3-(methoxymethoxy)pentane-1,5-diol(II),whichistreatedwithTs-OHandTEAinTHFtoyieldthedisulfonate(III).Thecondensationof(III)with5-ethoxyindolin-2-one(IV)bymeansoftBu-OKinTHFaffordsthespirocompound(V),whichisdeprotectedwithHClinmethanoltoaffordthespiranicalcohol(VI).Theoxidationof(VI)withpyridiniumchlorochromate(PCC)overAl2O3providesthespiraniccyclohexanone(VII),whichistreatedwith2-chloroethanol(VIII)andMs-OHintoluenetogivetheketal(IX).Thereactionof(IX)withzincborohydrideandtrimethylsilylchlorideinethylether/dichloromethaneyieldsthe2-chloroethoxyderivative(X),whichiscondensedwith4-(N-tert-butylcarbamoyl)-2-methoxybenzenesulfonylchloride(XI)bymeansoftBu-OKinTHFtoaffordtheadduct(XII).Finally,thetargetcompoundisobtainedbycondensationof(XII)withmorpholine(XIII)bymeansofNaIinDMF,followedbytreatmentwithfumaricacid.
16359-54-9C12H17ClN2185913-79-5C17H22ClNO3
402856-42-2C17H23Cl2NO65527-62-0C21H27N3O
8378-23-2C12H17NO1099-87-2C19H27NaO5S
99918-43-1C11H18Cl2N21445566-01-7C13H17NO
6740-85-8C12H13ClO1445583-20-9C18H26N4O2
14461-91-7C12H12N2O2612526-40-6C17H12BrFN4
39243-02-2C16H12BrN540054-69-1C17H15ClN4S
5650-44-2C10H13NO39742-60-4C13H17NO
13956-29-1C21H30O24021-34-5C17H26N2O
2426-63-3C17H27ClN2O1364933-55-0C23H22N2O
2894-68-0C16H12Cl2N2O39243-02-2C16H12BrN5
67579-76-4C18H26Cl2N2O33643-46-8C13H16